国际著名风湿病杂志（AnnRheumDis）上刊载了一篇有意思的论文。作者观察到在同样的遗传背景下，女性强直性脊柱炎病人母乳喂养的机会明显少于没有强直性脊柱炎的健康人，特别是得强直性脊柱炎的病人较其健康的兄弟姐妹母乳喂养的机会较少，母乳喂养可能是减少后代得强直性脊柱炎的较好方法。

作者推测有可能是母乳喂养更有利于建立健康的肠道微环境，而肠道菌群为主的肠道微环境在强直性脊柱炎的发病和病情进展中具有重要作用。这一消息对于准备孕育下一代的病友应该是一个非常有价值的信息。

Objective:Ankylosingspondylitis(AS)isachronicinflammatorydiseaseaffectingthespineandpelvisofyoungadults.OntheHLA-B27geneticbackground,theoccurrenceofASisinfluencedbytheintestinalmicrobiota.Thegoalofourstudywastotestwhetherbreastfeeding,whichinfluencesmicrobiota,canpreventthedevelopmentofAS.

Methods:First,patientswithHLA-B27-positiveASfulfillingthemodifiedNewYorkcriteriawererecruitedintheDepartmentofRheumatology,SteMargueritehospitalinMarseilles.Atotalofhealthysiblingswerealsorecruitedtomakeupacontrolgroupwithinthesamefamilies.Second,healthycontrols,andpatientswithrheumatoidarthritisandtheirsiblingswererecruited.Thedatacollectedwereage,gender,numberofbrothersandsisters,ageatdiseaseonset,typeanddurationoffeeding(breastorbottle).

Results:PatientswithAShadbeenbreastfedlessoftenthanhealthycontrols.Infamilieswherechildrenwerebreastfed,thepatientswithASwerelessoftenbreastfedthantheirhealthysiblings(57%vs72%),givinganORforASonsetof0.53(95%CI(0.36to0.77),pvalue=0.).BreastfeedingreducedfamilialprevalenceofAS.ThefrequencyofbreastfeedingwassimilarintheASsiblingsandintheunrelatedcontrols.However,patientswithASwerelessoftenbreastfed







































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