摘要

背景：有几个全国性的统计，发现强直性脊柱炎的患病率有很大的不同。本研究旨在描述在瑞典临床诊断强直性脊柱炎的患病率，根据年龄、性别、地域和社会经济因素的分层，并根据与强直性脊柱炎相关的临床表现和药物治疗的亚组进行分析。

方法：根据世界卫生组织的国际疾病分类，-年国家登记诊断为强直性脊柱炎的患者。搜集疾病表现，病人的人口统计资料、患者教育水平、药物治疗、地理区域的数据检索。

结果：在全国患者登记共例强直性脊柱炎患者，年患病率为0.18%。在瑞典北部的患病率较高，并具有较高的教育水平。与女性相比，男性强直性脊柱炎患病率更高（0.23%vs0.14%，P??0.），前葡萄膜炎发病率更高（25.5%vs20%，P＜0.?），更容易接受肿瘤坏死因子抑制剂（15.6%vs11.8%，P＜0.?）。女性比男性更容易发生外周关节炎（21.7%vs15.3%，P＜0.?），银屑病患病率无差异（8%vs6.9%，P=0.03??），口服糖皮质激素治疗有差异（14%vs10.4%，P＜0.)。

结论：在全国范围内注册为基础的研究表明，临床诊断强直性脊柱炎的患病率为0.18%。它揭示了在疾病的患病率方面两性之间的表型和治疗上以及地理和社会经济的差异。

Theprevalenceofclinicallydiagnosedankylosingspondylitisanditsclinicalmanifestations:anationwideregisterstudy

SofiaExarchou,UlfLindstr?m,JohanAskling,JonasKEriksson,HelenaForsblad-d’Elia,MartinNeovius,CarlTuresson,LarsErikKristensen,andLennartTHJacobsson

Abstract

Introduction

Prevalenceestimatesofankylosingspondylitisvaryconsiderably,andtherearefewnationwideestimates.ThepresentstudyaimedtodescribethenationalprevalenceofclinicallydiagnosedankylosingspondylitisinSweden,stratifiedaccordingtoage,sex,geographical,andsocio-economicfactors,andaccordingtosubgroupswithankylosingspondylitis-relatedclinicalmanifestationsandpharmacologicaltreatment.

Methods

AllindividualsdiagnosedwithankylosingspondylitisaccordingtotheWorldHealthOrganizationInternationalClassificationofDiseasecodes,betweenand,wereidentifiedfromtheNationalPatientRegister.Dataregardingdiseasemanifestations,patientdemographics,levelofeducation,pharmacologicaltreatment,andgeographicalregionwereretrievedfromtheNationalPatientRegisterandothernationalregisters.

Results

Atotalof11,caseswithanankylosingspondylitisdiagnosis(alive,livinginSweden,and16to64yearsoldinDecember)wereidentifiedintheNationalPatientRegister,givingapointprevalenceof0.18%in.TheprevalencewashigherinnorthernSweden,andlowerinthosewithahigherlevelofeducation.Menhadahigherprevalenceofankylosingspondylitis(0.23%versus0.14%,P??0.),ahigherfrequencyofanterioruveitis(25.5%versus20.0%,P??0.)andweremorelikelytoreceivetumornecrosisfactorinhibitorsthanwomen(15.6%versus11.8%in,P??0.).Womenweremorelikelythanmentohaveperipheralarthritis(21.7%versus15.3%,P??0.),psoriasis(8.0%versus6.9%,P?=?0.03),andtreatmentwithoralcorticosteroids(14.0%versus10.4%in,P??0.).

Conclusion

Thisnationwide,register-basedstudydemonstratedaprevalenceofclinicallydiagnosedankylosingspondylitisof0.18%.Itrevealedphenotypicalandtreatmentdifferencesbetweenthesexes,aswellasgeographicalandsocio-economicdifferencesindiseaseprevalence.

ArthritisResearchTherapy;17(1):.

编译者：医院临床免疫科韩青

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