作者：MontoyaJ,etal.翻译：北医三院李常虹（changhongli

摘要

目的：强直性脊柱炎是一种慢性炎症性疾病，可影响青壮年的脊柱和骨盆。在HLA-B27的遗传背景下，肠道菌群影响了强直性脊柱炎的发生。本研究旨在探讨哺乳是否可通过影响肠道菌群进而预防强直性脊柱炎的发生。

方法：首先，总共例HLA-B27阳性且符合改良的纽约分类标准的强直性脊柱炎患者被纳入本项研究。共例健康的直系亲属作为同一家庭的对照组也被纳入本项研究。其次，纳入了例健康对照和例类风湿关节炎及其直系亲属。收集年龄、性别、兄弟姐妹人数、发病年龄和哺乳持续时间。

结果：强直性脊柱炎患者较健康对照人群接受母乳喂养更少。在儿童时期接受母乳喂养的家庭中，得强直性脊柱炎的患者比他们健康的兄弟姐妹更少接受母乳喂养，强直性脊柱炎发生的比值比为0.53。母乳喂养降低了家族性强直性脊柱炎的患病率。强直性脊柱炎患者的兄弟姐妹接受母乳喂养的频率与例其他不相关的对照人群相似。然而，强直性脊柱炎患者本身接受母乳喂养的频率显著低于例其他不相关的对照人群（比值比0.6）。

结论：母乳喂养对于强直性脊柱炎的发病有保护作用，这是第一项针对强直性脊柱炎哺乳史开展的研究。

附原文：

AbstractOBJECTIVE:Ankylosingspondylitis(AS)isachronicinflammatorydiseaseaffectingthespineandpelvisofyoungadults.OntheHLA-B27geneticbackground,theoccurrenceofASisinfluencedbytheintestinalmicrobiota.Thegoalofourstudywastotestwhetherbreastfeeding,whichinfluencesmicrobiota,canpreventthedevelopmentofAS.METHODS:First,patientswithHLA-B27-positiveASfulfillingthemodifiedNewYorkcriteriawererecruitedintheDepartmentofRheumatology,SteMargueritehospitalinMarseilles.Atotalofhealthysiblingswerealsorecruitedtomakeupacontrolgroupwithinthesamefamilies.Second,healthycontrols,andpatientswithrheumatoidarthritisandtheirsiblingswererecruited.Thedatacollectedwereage,gender,numberofbrothersandsisters,ageatdiseaseonset,typeanddurationoffeeding(breastorbottle).RESULTS:PatientswithAShadbeenbreastfedlessoftenthanhealthycontrols.Infamilieswherechildrenwerebreastfed,thepatientswithASwerelessoftenbreastfedthantheirhealthysiblings(57%vs72%),givinganORforASonsetof0.53(95%CI(0.36to0.77),pvalue=0.).BreastfeedingreducedfamilialprevalenceofAS.ThefrequencyofbreastfeedingwassimilarintheASsiblingsandintheunrelatedcontrols.However,patientswithASwerelessoftenbreastfed







































治疗白癜风花多少钱
北京中科医院十二年致力公益事业


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